Sedriep S. et al., Beneficial nutraceutical modulation of cerebral erythropoietin expression and oxidative stress: an experimental study, J Biol Regul Homeost Agents. 2011 Apr-Jun; 25(2): 187-94.
In this study, mice that were administered Klamin® very significantly improved their learning ability. Moreover, their brain showed, besides a strong reduction of oxidation (MDA levels), an incredible increase of cerebral erythropoietin (EPO – +500%) and of its brain receptors (+300%). Cerebral EPO is the precursor of all neural stem cells, and thus contributes too brain and nervous system regeneration.
Cremonte M, Scoglio S et al., The effect of experimental supplementation with the Klamath Algae Extract Klamin® on Attention Deficit/ Hyperactivity Disorder, Journal of Medicinal Food, 20 (12) 2017, 1233–1239.
Here, Klamin® showed a powerful activity to minimize the symptoms of ADHD, such as hyperactivity and inattention, while improving the ability to perform functions in more efficient and precise ways. The authors found that Klamin® also improved the children’s symptoms of autism.
Scoglio S. et al., Selective MAO-B inhibition by an Aphanizomenon flos aquae extract and by its constitutive active principle phycocyanins and mycosporine-like amino acids, Phytomedicine, 2014 Mar 29,(14)00,123-8.
Klamin® contains molecules that are very powerful yet physiological MAO-B inhibitors. MAO-B are enzymes that destroys phenylethylamine (PEA), the main active principle of Klamin®, but also neurotransmitters such as dopamine and acetylcholine. Klamin® suspends the MAO-B activity without destroying the enzymes, which would cause potential side effects.
Genazzani A.D. et al., Effects of Klamath Algae extract on psychological disorders and depression in menopausal women: a pilot study. Minerva Ginecol. 2010 Oct;62(5):381-8.Italian.
Here, Klamin® significantly improved the psychological symptoms (depression, anxiety, low self-esteem) in post-menopausal women.
Scoglio S, Benedetti S, Genazzani AD et al., Effect of a 2-month treatment with Klamin, a Klamath algae extract, on the general well-being, antioxidant profile and oxidative status of postmenopausal women. Gynecol Endocrinol. 2009, Apr; 25(4): 235-40.
On a standard gynaecological scale, Klamin® improved both psychological and somatic (hot flushes, fatigue, libido) post-menopausal symptoms. Moreover, it very significantly improved the nutritional status of the women.
Bellingeri P., Scoglio S., Bonucci M., Complementary treatment of mood disturbances in terminally ill oncological patients with the Aphanizomenon flos aquae extract Klamin®, Adv Complement Alt Med. 1(3), 2018.
Administered to terminally ill cancer patients, undergoing only palliative care, Klamin® significantly improved their quality of life (depression, anxiety, and fatigue).
Lucca A. Catalano M., Scoglio S., Complementary treatment of depresses patients undergoing pharmacological therapy with a natural product based on Klamath algae and its proprietary extract Klamin® (unpublished).
Of 16 depressed subjects who had not responded to pharmacological treatments, once administered a very small quantity of Klamin® (500 mg.), half of them had a significant improvement of their condition.
Akinobu Tsunoo, M.D., Klamin®, an algae derived supplement, for depression (published in Japan).
16 moderately depressed patients substantially improved their condition with 1 gr. of Klamin® for 60 days, with no side effects.
Nuzzo D., Scoglio S. et al., Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model, Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 9089016, 14 pages.
In this very important study, performed at the National Research Center of Palermo, Italy, in which neuronal cells were stimulated to produce beta-amyloid substance, mimicking Alzheimer’s, Klamin® fully protected the neurons from any damage, reducing the production of beta-amyloid by more than 60% and, more importantly, by turning the 40% beta-amyloid still produce into a non-toxic substance.